Nutritional rickets: vitamin D, calcium, and the genetic make-up
نویسندگان
چکیده
منابع مشابه
Nutritional rickets: deficiency of vitamin D, calcium, or both?
Nutritional rickets remains a public health problem in many countries, despite dramatic declines in the prevalence of the condition in many developed countries since the discoveries of vitamin D and the role of ultraviolet light in prevention. The disease continues to be problematic among infants in many communities, especially among infants who are exclusively breast-fed, infants and children ...
متن کاملComparison of oral versus injectable vitamin-D for the treatment of nutritional vitamin-D deficiency rickets.
OBJECTIVE To assess the safety and acceptability of a single dose of vitamin-D versus the efficacy of injectable Vitamin-D versus oral vitamin-D. STUDY DESIGN Case control. PLACE AND DURATION OF STUDY It was carried out at the Department of Paediatrics, Kharadar General Hospital, Karachi, from August 2003 to April 2004. METHODOLOGY Children of the age of 6 months to 3 years with clinical,...
متن کاملA comparison of calcium, vitamin D, or both for nutritional rickets in Nigerian children.
BACKGROUND Nutritional rickets remains prevalent in many tropical countries despite the fact that such countries have ample sunlight. Some postulate that a deficiency of dietary calcium, rather than vitamin D, is often responsible for rickets after infancy. METHODS We enrolled 123 Nigerian children (median age, 46 months) with rickets in a randomized, double-blind, controlled trial of 24 week...
متن کاملVitamin D-dependent Rickets
1,25(0H)2D3 induces 25(OH)D3-24-hydroxylase (24-OHase) in cultured skin fibroblasts from normal subjects. We evaluated 24-OHase induction by 1,25(0H)2D3 in skin fibroblasts from 10 normal subjects and from four unrelated patients with hereditary resistance to 1,25(OH)2D or vitamin D-dependent rickets type II (DD II). Fibroblasts were preincubated with varying concentrations of 1,25(0H)2D3 for 1...
متن کاملGenetic aspects of nutritional rickets.
Amino acid excretion was investigated in 21 rachitic infants and in 22 of their parents. There was (a) increased alpha-amino acid excretion in one-third of the infants a long time after the rickets had healed, (b) an abnormally high excretion of alpha-amino nitrogen and of phosphorus in many of the parents (c) an abnormal pattern of amino acid excretion in all 9 infants tested, and (d) a good c...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2016
ISSN: 0031-3998,1530-0447
DOI: 10.1038/pr.2016.222